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Quercetin stabilizes mast cells and inhibits the release of histamine.[ref] Related article: Mast Cell Activation Syndrome Genes Caffeine and quercetin (CYP1A2 gene): Quercetin inhibits CYP1A2, which is the enzyme the body uses to metabolize caffeine.[ref] If you are a slow metabolizer of caffeine, quercetin along with caffeine, may mean that you feel the effects of caffeine for a longer period of time